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KMID : 0360419940300030331
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Korean Journal of Pharmacology
1994 Volume.30 No. 3 p.331 ~ p.336
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Possible Role of Nitric Oxide in Prevention of Atherosclerosis: Photo-induced adequate nitric oxide (PIANO)-mediated relaxation involves cyclic GMP increment
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Chang Ki-Churl
Chong Won-Seog
Park Byung-Wook
Lee Seung-Youb
Ko Hak-Joon
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Abstract
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Our purpose was to know whether photo-induced adequate nitric oxide (PIANO)-mediated relaxation of rat aorta is involved in cyclic GMP increment as well as inhibition of phosphatidylinositide hydrolysis due to phenylephrine (PE). Isometric tension was measured in vitro in response to either agents that modulate NO production or release NO by photolysis of photosensitizing agents in rat aorta that had been contracted with PE submaximally. PIANO-mediated relaxation was accompanied by increment of cyclic GMP, which was dependent on the intensity and duration of light exposure and concentration of photosensitizers. Phosphatidylinositide (PI) turnover augmented by PE was significantly inhibited by PIANO. These findings indiate that cGMP increment is responsible for PIANO-mediated relaxation and which may account for the inhibition of PI turnover due to α-adrenergic receptor stimulation.
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KEYWORD
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Photorelaxation, cGMP, Phosphoinositide, Rat aorta
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